Press Release

National Advertising Division Recommends Agendia Modify or Discontinue Certain Claims for MammaPrint and BluePrint Breast Cancer Tests

New York, NY – June 13, 2024 – In a challenge brought by Genomic Health, Inc., a wholly owned subsidiary of Exact Sciences Corporation (GHI), BBB National Programs’ National Advertising Division recommended that Agendia, Inc. modify or discontinue certain claims regarding the superiority of its MammaPrint and BluePrint tests for black women, including claims that GHI’s Oncotype DX test is inappropriate for black women and that it is biased, inaccurate, and inconsistent.

GHI’s Oncotype DX test and Agendia’s MammaPrint and BluePrint genomic tests assess the risk of breast cancer recurrence in early-stage breast cancer patients.

The challenged claims appeared in sponsored advertising content, in posts on all major social media platforms, and on the Agendia website. Agendia’s advertisements are provided to doctors, other medical professionals, breast cancer patients, and caregivers.

Equality of Care/Bias Claims

GHI challenged a two-sided postcard distributed to healthcare professionals with the headline that Agendia and its tests provide “EQUAL CARE FOR ALL” and that “Agendia is committed to addressing racial disparities in breast cancer,” followed by claims including:

  • “Black women are more likely to die from breast cancer than white”
  • “Only MammaPrint & BluePrint results can identify higher risk ER+ tumors in black women”
  • “Agendia’s test provide consistent results in black women as well as in other diverse groups of patients”
  • “Oncotype DX Breast RS test has lower prognostic accuracy in Black women”

The bottom of the postcard says, “Not all Genomic Tests are Created Equal.”

The other side of the postcard shows a comparative chart between the “MammaPrint & BluePrint” vs. “Onctoype DX” and a series of checkmarks indicating differences between the tests. The chart concludes with the claim “EQUAL CARE FOR ALL” checked “yes” for MammaPrint & BluePrint, with no checkmark for Oncotype DX.

The National Advertising Division (NAD) determined that at least one message reasonably conveyed by this advertisement and comparative chart is that GHI does not want equal care for all, a message not supported by the evidence in the record.

Further, NAD concluded that Agendia’s evidence does not provide a reasonable basis for the claim that the Onctoype DX test is biased (along with the negative connotation implied by the word “bias”) and that the MammaPrint test has uncovered this bias.

Therefore, NAD recommended Agendia either discontinue these claims or modify its advertising to avoid conveying the falsely disparaging messages that GHI does not want equal care for all and that its Onctoype DX test is biased.

Superiority/Singularity for Tumor Identification Claims

The National Advertising Division (NAD) determined that Agendia’s evidence does not provide a reasonable basis for the overly broad message conveyed by the claim “Only MammaPrint & BluePrint results can identify higher risk ER+ tumors in black women,” which appeared on the postcard. Therefore, NAD recommended that Agendia either discontinue the claim or modify it to more accurately reflect the underlying support.

Accuracy of Test Results/Inconsistent Results Claims

The National Advertising Division (NAD) recommended Agendia discontinue claims that MammaPrint results provide “more accurate predictions” because the evidence does not support that it is “more” accurate than either prior or competing tests and because the test is not cleared or indicated as a predictive test.

GHI also challenged several claims questioning the reliability of Oncotype DX, a test that Agendia characterized as having lower accuracy in black women and inconsistent results.

NAD determined that the studies Agendia relied on are not a good fit for claims that broadly communicate that Onctotype DX has lower prognostic accuracy or worse outcomes for black women.

Therefore, NAD recommended Agendia discontinue the challenged claims or modify its advertising to avoid conveying the overly broad message that Oncotype DX has lower prognostic accuracy and provides less consistent results for black women than MammaPrint and BluePrint. NAD noted that nothing in its decision prevents Agendia from accurately communicating the results of the studies in a more narrowly tailored manner.

Worse Outcomes for Black Women Claims

The National Advertising Division (NAD) recommended that Agendia discontinue claims that attribute worse outcomes for black women with the same Oncotype DX test results as white women or modify the claims to avoid conveying such a message.

Material Connection Disclosures

GHI asserted that Agendia posted articles published by Hit Consultant and Stat News featuring Dr. Johnson’s opinions on MammaPrint and Oncotype tests on social media that do not include the material connection disclosures required by the FTC’s Guides Concerning Use of Endorsements and Testimonials in Advertising. Since Agendia confirmed that it does not have a relationship, paid or otherwise, with Dr. Johnson, Stat News, or Hit Consultant, the National Advertising Division (NAD) determined there are no material connection disclosures required on the challenged posts. 

In its advertiser statement, Agendia stated that it will comply with NAD’s recommendations although it “respectfully disagrees with NAD regarding both the interpretation of and the substantiation for Agendia’s advertising” and “has no current plans to resume the challenged claims.”

All BBB National Programs case decision summaries can be found in the case decision library. For the full text of NAD, NARB, and CARU decisions, subscribe to the online archive. This press release shall not be used for advertising or promotional purposes.

 

About BBB National Programs: BBB National Programs, a non-profit organization, is the home of U.S. independent industry self-regulation, currently operating more than a dozen globally recognized programs that have been helping enhance consumer trust in business for more than 50 years. These programs provide third-party accountability and dispute resolution services that address existing and emerging industry issues, create a fairer playing field for businesses, and a better experience for consumers. BBB National Programs continues to evolve its work and grow its impact by providing business guidance and fostering best practices in arenas such as advertising, child-and-teen-directed marketing, data privacy, dispute resolution, automobile warranty, technology, and emerging areas. To learn more, visit bbbprograms.org.

About the National Advertising Division: The National Advertising Division of BBB National Programs provides independent self-regulation and dispute resolution services, guiding the truthfulness of advertising across the U.S. The National Advertising Division reviews national advertising in all media and its decisions set consistent standards for advertising truth and accuracy, delivering meaningful protection to consumers and leveling the playing field for business.

See Campaign: https://bbbnp.org

Contact Information:

Name: Jennie Rosenberg
Email: [email protected]
Job Title: Media Relations

Tags:
BNN, CE, Go Media, Go Media2, GoInvest, Google News, iCN Internal Distribution, IPS, Nexis Newswire, PR-Wirein, Reportedtimes, The Newswire, English

Contact Information:

Name: Jennie Rosenberg
Email: [email protected]
Job Title: Media Relations

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    A sarcophagus discovered in 2009 in an Egyptian burial chamber came with a complicated history: Ancient writing on the stone container showed that it had been used twice, but while its second occupant, the 21st dynasty high priest Menkheperre, was known, the first owner had remained a mystery — until now.

    New clues have surfaced as a result of Frederic Payraudeau, an associate professor in Egyptology at Sorbonne University in Paris, reexamining a fragment of the granite sarcophagus and deciphering the hieroglyphs engraved on it. Tucked away in the cartouche, an oval-shaped ornament often found in tombs, he found a name of a very recognizable figure: Ramesses II.
    Payraudeau said the inscription is evidence that the artifact was originally from the tomb of the famous pharaoh and had been reused after looting.

    “Clearly, this was the sarcophagus of a king,” Payraudeau said. “The cartouche dates back to its first usage, and contains Ramesses II’s throne name, Usermaatra. He was the only pharaoh to use this name during his time, so that cleared any doubt that it was his sarcophagus.”

    The findings, published in the journal Revue d’Egyptologie, add to the lore of Ramesses II, also known as Ozymandias and one of Egypt’s most celebrated pharaohs. It also fills a gap in our understanding of how sarcophagi were used to entomb kings.
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    Another coffin belonging to Ramesses II was discovered in 1881 near Luxor, but the sarcophagus fragment analyzed in the study was found in Abydos, a city about 40 miles (64 kilometers) to the northwest in a straight line.

    “That is less bizarre than it seems,” Payraudeau said, “because we know his tomb was looted in the antiquity, maybe two centuries after his death, and he’s certainly not the only king to have been looted.”

    The granite fragment, which is a nearly complete part of the longer side of the sarcophagus, was previously believed to have belonged to a prince. “But I always found this strange, because the decoration on this carefully crafted piece was indicative of a king, and had elements traditionally reserved for kings,” Payraudeau said.

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