The organoids and spheroids market are growing at a steady pace on account of the innovation in the tissue culture system and frequent failures in organ transplantation surgeries, and the technological developments in the 3D spheroid technology. The growth of the organoids and spheroids market is further driven by the surging demand for organoid-based research models in the developed regions and the increased application of organoid culture in drug discovery. Both organoid and spheroid technology has been extensively used in personalized medicine, disease modeling, and optimizing drug discovery and regenerative medicine. Mainly, the application of organoids is gaining considerable momentum in CRISPR research that could potentially help scientists and researchers better interpret organ development from the perspective of gene editing.
On the other hand, spheroids can also be utilized to study stem cells to develop embryoid bodies from stimulated pluripotent stem cells, which can be turned into high-purity stem cells effective in research on neural diseases and their related treatment. Though these 3D structures are used in the most gene-related study, recent improvements in organoids and spheroids proliferation/viability have substantially improved its feasibility in analyzing human disorders and drug screening. The increased visibility of organoids and spheroids allows for the development of cohesive spheroids and facilitates the scientists to direct the cell activities by regulating the culture microenvironment. Following these promising developments, the Global Organoids and Spheroids Market is estimated to see healthy growth, pegged at a CAGR of around 19.8% throughout the forecast period 2021-2027.
In recent years, organoids and spheroids have emerged as a novel model for performing research or studying cholestatic liver injury and cholangiocarcinoma. Traditional 2D monolayer cell cultures cannot resemble intercellular cell?to?cell interaction; however, 3D cell culture systems, such as organoids and spheroids, have been developed to mimic cellular interaction and architecture between hepatic cells. These 3D cell structure systems, such as organoids and spheroids, have functional attributes suitable for drug screening, allowing its users to monitor cell-to-cell interaction to interpret the disease’s progression better. Furthermore, Organoids and spheroids also grab the wide attention of the healthcare industry owing to their promising application and significant advances in supportive fields, including tissue engineering, stem cells, gene therapy, drug discovery, and nanotechnology.
In the wake of COVID-19, the application of organoids and spheroids has been increased to reveal the impact of the SARS-CoV virus on several intestinal cells and lungs framework. Apart from this, scientists and healthcare professionals have been utilizing these 3D structures to identify and test several promising medications. Many companies have engaged in the development of these systems before the outbreak of the COVID-19 pandemic. For example, Agilent Technologies has created a spheroid microplate that facilitates the measurement of cellular energy metabolism, whereas Corning’s developed spheroid microplates and HTS Transwell tissue culture systems for high-output culturing. These efforts have led to demonstrate drug response and tumor morphology. As such, organoids and spheroids play a pivotal role in tapping lucrative opportunities into the growing power of 3D research during the COVID-19 pandemic and in the subsequent years.
Segmentation Overview of the Global Organoids and Spheroids Market
The organoids and spheroids market is segmented into organoid type, spheroid type, application, and end-user. These major market segments are further categorized into various sub-segments to study the market in detail.
By Organoid Type Outlook (Neural Organoids, Hepatic Organoids, Intestinal Organoids, and Others)
By Spheroid Type Outlook (Multicellular Tumor Spheroids, Neurospheres, Mammospheres, Hepatospheres, and Others)
By Application Outlook (Developmental Biology, Regenerative Medicine, Personalized Medicine, Drug Toxicity and Efficacy Testing, and Others)
By Specimen Outlook (Biotechnology and Pharmaceutical Industries, Hospitals and Diagnostic Centers, Academic and Research Institutes, and Others)
Key Players Insights
Thermo Fisher Scientific, Inc., Merck KGaA, Lonza Group, 3D Biomatrix, 3D Biotek LLC, AMS Biotechnology (Europe) Limited, Cellesce Ltd, Corning Incorporated, Greiner Bio-One, Hubrecht Organoid Technology (HUB), InSphero/Perkin Elmer, Prellis Biologics, Stemcell Technologies, Inc., among others, are some key market players included in the research study of the global organoids and spheroids market.
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